Nonclinical - often referred to as preclinical - services encompass toxicology, pharmacology, metabolism, bioanalysis, pharmaceutical analysis, and biosafety testing in support of nonclinical drug development. Nonclinical testing is conducted throughout all phases of drug development. Sound nonclinical development maximizes the chances of success in the clinical phases. CCDRD offers comprehensive services in all of these areas within the broad context of a thorough understanding of the regulatory, scientific, and commercial environments.
The focus of bioanalysis is to provide a quantitative measure of the active drug and/or its metabolites. Samples may be derived from cell culture media or from plasma, serum, or urine. Bioanalytical services range from late discovery to clinical studies. Depending on the chemical nature, the molecular weight and structure of the drug, the level of the drug/metabolite, and the matrix (serum, plasma, urine, or culture media), an appropriate bioanalytical technique is required. CCDRD AG provides a broad range of Bioanalytical services from standalone chromatographic techniques to mass spectrometry techniques as well as immunochemical methods.
| Analyte |
| 3-Keto desogestrel |
| 4-Methylaminophenazon |
| 5-Aminosalicylic acid / Ac-5- ASA |
| 6-Mercaptopurine |
| Aceclofenac |
| Acetaminophen |
| Acetazolamide |
| Acetylcystein |
| Acetylsalicylic acid |
| Acyclovir |
| Adefovir Dipivoxil |
| Alendronate |
| Alfuzosin |
| Allopurinol; Oxypurinol |
| Alprazolam |
| Amiloride |
| Amiodarone; Desethylamiodarone |
| Amisulpride |
| Amitriptyline |
| Amlodipine |
| Amoxycillin |
| Amphetamine (chiral method) |
| Ampicillin |
| Anagrelide |
| Anastrozole |
| Androstenedione |
| Antipyrine |
| Apomorphine |
| Aprepitant |
| Aripiprazole |
| Armodafinil |
| Arsenic |
| Aspirin |
| Atenolol |
| Atomoxetine |
| Atorvastatin and metabolites |
| Atovaquone |
| Azithromycin |
| Baclofen |
| Balsalazide |
| Bay9798 |
| Benazepril; Benazeprilat |
| Benserazide |
| Benzylpenicillin |
| Betamethasone Phosphate |
| Betamethasone; Betamethasone Acetate |
| Bezafibrate |
| Bicalutamide |
| Bilobalide |
| Bisoprolol |
| Bromazepam |
| Bromide |
| Brompheniramine |
| Buflomedil |
| Bumetanide |
| Bupivacaine |
| Buprenorphine;Norbuprenorphine |
| Bupropion; Hydroxybupropion; Erythrohydroxybupropion; Threohydroxybupropion |
| Buspirone; 1-(2-pyrimidyl) piperazine |
| Butorphanol |
| Cabergoline |
| Caffeine |
| Calcitonin (human) |
| Calcitriol |
| Candesartan |
| Capecitabine |
| Captopril |
| Carbamazepine; 10,11-Epoxide Carbamazepine |
| Carbidopa |
| Carisoprodol |
| Carvedilol; 4'-Hydroxyphenylcarvedilol |
| Cefaclor |
| Cefadroxil |
| Cefatrizine |
| Cefdinir |
| Cefetamet |
| Cefixime |
| Cefpodoxime |
| Cefprozil (Z)-Isomer and Cefprozil (E)-Isomer |
| Cefuroxime |
| Celecoxib |
| Cephalexin |
| Cetirizine |
| Chloramphenicol |
| Chlormadinone acetate and metabolite |
| Chloroquine |
| Chlorpheniramine |
| Chlorpromazine |
| Chlortetracycline |
| Ciclopirox |
| Ciclopirox-glucuronide |
| Cilasapril and metabolite |
| Cilostazol |
| Cimetidine |
| Cinacalcet |
| Ciprofibrate |
| Ciprofloxacin |
| Cisapride; Norcisapride |
| Citalopram |
| Cizolirtine; Desmethylcizolirtine |
| Clarithromycin and metabolite |
| Clavulanic Acid |
| Clindamycin |
| Clobutinol |
| Clodronic acid |
| Clofibrate |
| Clomifen (enantioselective) |
| Clomipramine |
| Clonazepam |
| Clonidine |
| Clopidogrel+Metabolites |
| Clotrimazole |
| Clozapine; N-Desmethylclozapine |
| Cocaine |
| Codeine, Norcodeine and Codeine-6-Glucuronide |
| Colchicine |
| Cortisol |
| Cyclizine + Nor |
| Cycloserine |
| Cyclosporin A |
| Cyproterone Acetate |
| Cytarabine and ARA-U |
| Darifenacin |
| Daunorubicin; Daunorubicinol |
| Dehydroepiandrosterone (DHEA) |
| Dehydroepiandrosterone Sulfate (DHEAS) |
| Descarboethoxy Loratadine; 3-Hydroxy Desloratadine |
| Desipramine; 2-Hydroxydesipramine |
| Desloratadine |
| Desogestrel (3-Ketodesogestrel) |
| Dexamethasone / Dexamethasone phosphate |
| Dextromethorphan; Dextrorphan |
| Dialk(en)yldisulfides |
| Diazepam |
| Diazoxide |
| Diclofenac |
| Didanosine |
| Digoxin |
| Dihydroergotamine |
| Dihydrotachysterol |
| Diltiazem, N-Desmethyldiltiazem; Deacetyldiltiazem |
| Dimenhydrinate |
| Dimethyl Sulfoxide |
| Diphenhydramine |
| Dipyridamole |
| Dipyrone(4MAA) |
| Disulfiram |
| DMSO + DMSO2 |
| Docetaxol |
| Donepezil |
| Dothiepin |
| Doxepin / Nordoxepin (cis-trans) |
| Doxycycline |
| Doxycycline Ephedrine |
| Doxylamine |
| Doxylamine succinate |
| Drospirenone |
| D-Threo-Methylphenidate; L-Threo-Methylphenidate |
| Duloxetine |
| Ebastine; Carbastine |
| Efavirenz |
| Eletriptan; Desmethyl eletriptan |
| Enalapril; Enalaprilat |
| Eniluracil |
| Entacapone |
| Ephedrine |
| Epirubicin;Epirubicinol |
| Eplerenone |
| Erlotinib |
| Erythromycin; Erythromycin Ethylsuccinate |
| Erythropoietin |
| Escitalopram |
| Esomeprazole |
| Estradiol; 17 Beta |
| Estramustine |
| Estromustine |
| Estrone |
| Estrone Conjugates |
| Estrone; Estradiol |
| Eszopiclone |
| Ethambutol |
| Ethanol |
| Ethinyl Estradiol;Gestodene; Nestorone |
| Etidronic Acid |
| Etodolac |
| Etoposide |
| Exemestane |
| Ezetimibe (and glucuronide) |
| Famotidine |
| Felbinac |
| Felodipine |
| Fenbendazole |
| Fenipentol (Phenylpentanol) |
| Fenofibrate |
| Fentanyl |
| Fexofenadine |
| Finasteride |
| Flecainide |
| Flosequinan; Sulfone Metabolite |
| Flubendazol |
| Flucloxacillin |
| Fluconazole |
| Flunitrazepam |
| Fluorouracil |
| Fluoxetine;Norfluoxetine;Ondansetron |
| Flurbiprofen |
| Flutamide |
| Flutamide / Hydroxyflutamide |
| Fluticasone |
| Fluvastatin |
| Fluvoxamine |
| Fosinopril |
| Fosinoprilat |
| FSH (Follicle Stimulating Hormone) |
| Furosemide |
| Gabapentin |
| Galanthamine |
| Gatifloxacin |
| Gemcitabine |
| Gemfibrozil |
| Genistein |
| Gentamicin |
| Gestodene |
| Gingkolides A and B |
| Glibenclamide |
| Gliclazide |
| Glimepirid |
| Glimepiride |
| Glipizide |
| Glucose |
| Glucosinolate (Sinigrin, Gluconasturtiin, Glucotropaeolin) |
| Glyburide |
| GTN / GDN's |
| Halobetasol Propionate |
| Haloperidol |
| Human Growth Hormone(hGH) |
| Hydrochlorothiazide |
| Hydrocodone |
| Hydromorphone |
| Hydroquinone |
| Hydroxy Acid Lovastatin |
| Hydroxybupropion |
| Hydroxyflutamide |
| Hydroxyurea |
| Ibandronic Acid |
| Ibuprofen (Enantiomers) |
| Imatinib;desmethyl imatinib |
| Imipramine; Desipramine |
| Indapamide |
| Indomethacine |
| Insulin-like Growth Factor-1(IGF-1) |
| Interferon alpha2b |
| Ipsapirone |
| Irbesartan |
| ISDN |
| ISMN |
| Isoniazid |
| Isosorbide 5-Mononitrate |
| Isothiocyanate, Allyl-, Benzyl-, Phenethyl- |
| Isotretinoin |
| Isradipine |
| Itraconazole |
| Ketoconazole |
| Ketophenylbutazone |
| Ketoprofen |
| Ketotifen |
| Lacidipine |
| Lamivudine |
| Lamotrigine |
| Lansoprazole |
| L-Citrulline |
| L-DOPA |
| Leflunomide (main metabolite A77 1726) |
| Lercarnidipine (enantioselective) |
| Letrozole |
| Leukotriene B4 |
| Levetiracetam |
| Levocetirizine |
| Levodopa and metabolites |
| Levofloxacine |
| Levonorgestrel |
| Levothyroxine (T4) |
| Lidocaine |
| Lincomycine |
| Linezolide |
| Liothyronine |
| Lipoic acid |
| Lisinopril |
| Lithium |
| Lofepramine |
| Loperamide |
| Loratadine; Descarboethoxy Loratadine |
| Lorazepam |
| Losartan; Losartan Carboxy Acid |
| Lovastatin |
| Luteinizing Hormone (LH) |
| Medroxyprogesterone Acetate |
| Mefenamic acid |
| Megestrol Acetate; Hydroxymethyl Megestrol; Acetoxy Hydroxymethyl Megestrol; Acetoxy Dihydroxymethyl Megestrol |
| Meloxicam |
| Memantine |
| Mesalamine (5-ASA) |
| Metaxalone |
| Metformin |
| Methamphetamine |
| Methyldopa |
| Methylphenidate and Ritalinic acid |
| Methylprednisolone |
| Metoclopramide |
| Metolazone |
| Metoprolol (R)-(+) and (S)-(-) |
| Metronidazole |
| Mianserin |
| Mianserin; Normianserin |
| Midazolam; 1-OH-Midazolam |
| Minocycline |
| Mirtazapine |
| Misoprostol Acid |
| Modafinil |
| Molsidomine; Linsidomine |
| Montelukast |
| Morphine; Morphine-6-Glucuronide; Morphine-3-Glucuronide |
| Moxifloxacin |
| Mycophenolate Mofetil |
| Mycophenolic acid + glucuronide |
| Nabumetone; 6-methoxy-2-naphtaleneacetic acid |
| N-Acetyl-L-Cysteine |
| Naftidrofuryl |
| Naloxone; 6-Beta-Hydroxy-Naloxol |
| Naltrexone; 6ß-naltrexol |
| Naproxen |
| Naratriptan |
| Nateglinide |
| Nebivolol |
| Nefazodone; Hydroxy Nefazodone and M-chlorophenylpiperazin |
| Neurosteroids |
| Nevirapine |
| Niacin;Nicotinuric acid |
| Nicardipine |
| Nicergoline |
| Nicethamide |
| Nicorandil |
| Nicotine metabolite: Cotinine |
| Nifedipine |
| Nimesulide |
| Nimodipine |
| Nitrazepam |
| Nitrendipine |
| Nitrofurantoin |
| Nitroxoline |
| Nizatidine and N-2-monodesmethylnizatidine |
| Nomegestrol |
| Norethindrone |
| Norfloxacin |
| Norgestimate; 17-deacetyl norgestimate and Levonorgestrel |
| Norpseudoephedrine |
| Norselegiline |
| Nortilidine |
| Nortriptyline; E-10-hydroxy nortriptyline |
| Noscapin |
| Octreotide |
| O-desmethyltramadol |
| Ofloxacine |
| o-hydroxy-atorvastatin |
| Olanzapine |
| Olmesartan |
| Omeprazole |
| Ondansetron |
| Opipramol |
| Ornidazol |
| Ornidazole |
| Oseltamivir |
| Oxandrolone |
| Oxcarbazepine; 10-Hydroxycarbamazepine |
| Oxybutazone |
| Oxybutynin; N-Desethyloxybutynin |
| Oxycodone metabolite: Nor-oxymorphone |
| Oxymorphone metabolite: 6-OH Oxymorphone |
| Oxypurinol |
| Oxytetracycline |
| Paclitaxel |
| Pantoprazole |
| Paracetamol |
| Paricalcitol |
| Paroxetine |
| Pemetrexed |
| Penciclovir |
| Penicillin |
| Penicillin G |
| Penicillin V |
| Pentazocine |
| Pentoxifylline and metabolites |
| Pergolide |
| Perindopril; Perindoprilat |
| Petasine |
| Phenazone |
| Phenprocoumon |
| Phenylbutazone |
| Phenylephrine |
| Phenytoin |
| Pinaverium |
| Pioglitazone; Hydroxypioglitazone; Ketopioglitazone |
| Piracetam |
| Piretanide |
| Pirlindole |
| Piroxicam |
| Platinum (Free) |
| Platinum (Total) |
| Plumbagin |
| Polymyxin |
| Polymyxin B |
| Polymyxin E |
| Potassium |
| Pramipexole |
| Pravastatin; 3-a-hydroxy Pravastatin |
| Prednisolone / Prednisolone esters |
| Prednisolone Proglumide |
| Prednisone |
| Prednisone; Prednisolone |
| Pregabalin |
| Primidone |
| Proflavine |
| Progesterone |
| Proglumide |
| Promazine |
| Promethazine |
| Propafenone (Enantiomers) |
| Propanolol Total; 4-Hydroxypropanolol |
| Propiverine (plus metabolite) |
| Propofol |
| Propranolol Total; 4-hydroxypropranolol |
| Propylene glycol |
| Propyphenazone |
| Pseudoephedrine |
| Pyrazinamide |
| Pyridium |
| Pyridoxal |
| Pyridoxal-5-Phosphate |
| Pyridoxamine |
| Pyridoxamine 5-phosphate |
| Pyridoxine |
| Pyritanol |
| Quetiapine |
| Quinapril; Quinaprilat |
| Quinidine |
| Quinine |
| R-(-)-Bicalutamide and S-(+)-Bicalutamide |
| R-(-)-Bicalutamide; S-(+)-Bicalutamide |
| R-(+)-Sibutramine; S-(-)-Sibutramine |
| R/S-Zopiclone (chiral method) |
| Rabeprazole |
| Racecadotril |
| Raloxifene |
| Raloxifene-4'-glucuronide; Raloxifene-6-glucuronide |
| Ramipril; Ramiprilat |
| Ranitidine |
| Repaglinide |
| Reserpine |
| Rhein |
| Ribavirin |
| Rifampicin |
| Rifaximin |
| Risedronate |
| Risperidone; 9-hydroxyrisperidone |
| Ritalinic acid |
| Ritodrine |
| Ritonavir |
| Ritordrine |
| Rivastigmine and metabolite |
| Rizatriptan |
| Rofecoxib |
| Ropinirole |
| Rosiglitazone |
| Rosuvastatin |
| Roxythromycin |
| R-Selegiline, N-Desmethyl Selegiline, L-Amphetamine and L-Methamphetamine |
| Salbutamol |
| Salicylic acid |
| Salmeterol |
| Scopolamine |
| Selegiline metabolites |
| Sertralin |
| Sertraline |
| Sibutramine; N-Mono-desmethyl-sibutramine; N-di-desmethyl-sibutramine |
| Sildenafil; Desmethyl sildenafil |
| Silver |
| Simvastatin; ß-Hydroxy Acid Simvastatin |
| Sirolimus |
| Sorafenib |
| Spectinomycine |
| Spironolactone and Canrenone |
| Stavudine |
| Sulbactam |
| Sulfadiazine |
| Sulfadimethoxin |
| Sulfadimidine |
| Sulfadoxin |
| Sulfamerazine |
| Sulphamethizole |
| Sulphamethoxazole |
| Sulpiride |
| Sumatriptan |
| Sunitinib |
| Synephrine |
| Tacrolimus |
| Tadalafil |
| Tamoxifen; N-desmethyl-tamoxifen |
| Tamsulosin |
| Tegaserod |
| Telmisartan |
| Temazepam |
| Tenoxicam |
| Terazosin |
| Terbinafine |
| Testosterone |
| Tetracycline |
| Theobromine |
| Theophylline |
| Thiocolchicoside |
| Thiorphan |
| Tibolone, 3-Alpha Hydroxytibolone and 3-Beta Hydroxytibolone |
| Ticlopidine |
| Tilidine (as nortilidine) |
| Tilidine metabolite |
| Timolol |
| Tizanidine; Tizanidine-M4 |
| Tobramycin |
| Tolperisone |
| Tolterodine; 5-hydroxymethyl Tolterodine |
| Topiramate |
| Torasemide |
| Tramadol;o-desmethyltramadol |
| Trandolapril; Tradolaprilat |
| Tranexamic acid |
| Tranylcypromine |
| Trazodone |
| Triamcinolone Acetonide |
| Trimetazidine |
| Trimethoprim |
| Trimipramine |
| Trospium |
| Tucaresol |
| Tylosin |
| Ursodiol;Tauroursodeoxycholic Acid;Glycoursodeoxycholic Acid |
| Uzarin and uzarigenin |
| Valacyclovir |
| Valproic Acid |
| Valproic Acid Glucuronide |
| Valsartan |
| Vardenefil |
| Venlafaxine; O-desmethyl-venlafaxine |
| Verapamil; Normethylverapamil (Chiral) |
| Vinorelbine |
| Vinyldithiine |
| Vitamin C |
| Voriconazole |
| Warfarin (Enantiomers) |
| Xipamide |
| Zaleplon |
| Zidovudine |
| Ziprasidone |
| Zolendronic Acid |
| Zolmitriptan;N-desmethylzolmitriptan |
| Zolpidem |
| Zonisamide |
